Worst Pills
omeprazole (PRILOSEC, PRILOSEC OTC)

Drug and Dietary Supplement Profiles

A comprehensive review of the safety and effectiveness of this drug. If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to use the medication are included.
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Disease and Drug Family Information

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  • Combination Treatments for Helicobacter Pylori Infection [hide all summaries]
    The bacterium Helicobacter pylori (H. pylori) has been implicated in causing ulcer disease. The combination treatments described have high success rates and low recurrence rates, but the treatment is arduous.
  • Ulcers and Gastroesophageal Reflux Disease (GERD) [hide all summaries]
    There are nondrug treatments, with no safety concerns, and less expensive drugs that may be effective for GERD; these should be tried before you use any drugs for heartburn. First, try to avoid foods that trigger your condition (e.g., fatty foods, onions, caffeine, peppermint, and chocolate), and avoid alcohol, smoking, and tight clothing. Second, avoid food, and particularly alcohol, within two or three hours of bedtime. Third, elevate the head of the bed about six inches or sleep with extra pillows.

Worst Pills, Best Pills Newsletter Articles

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Additional Information from Public Citizen

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  • Petition Urging FDA to Add Warnings to Proton Pump Inhibitors (HRG Publication #1964) [hide all summaries]
    Public Citizen petitions the FDA to immediately add black box warnings and other safety information concerning several severe risks to the product labels of all proton pump inhibitors (PPIs) presently on the market in the U.S. In addition, the serious nature of so many of these adverse reactions also mandates the requirement for FDA-approved patient Medication Guides, none of which exist now, for all of these drugs.

Health Letter Articles

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  • Proton-Pump Inhibitors: Dangerous and Habit-Forming Heartburn Drugs [hide all summaries]
    (September 2011)
    PPIs are now one of the most widely used classes of prescription drugs, with an estimated one out of every 20 people in the developed world currently taking one of these medications. However, given that recent research shows PPIs may be habit-forming, that the majority of PPI use is probably inappropriate, with minimal or no benefit to the patient, and that new, life-threatening risks with long-term therapy are continually emerging, it is time for the medical community to re-evaluate the role of PPIs in everyday practice.

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